S 1 Metal - substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity
نویسندگان
چکیده
منابع مشابه
Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity.
Engineered metalloproteins constitute a flexible new class of analyte-sensitive molecular imaging agents detectable by magnetic resonance imaging (MRI), but their contrast effects are generally weaker than synthetic agents. To augment the proton relaxivity of agents derived from the heme domain of cytochrome P450 BM3 (BM3h), we formed manganese(III)-containing proteins that have higher electron...
متن کاملA New Potential Contrast Agent for Magnetic Resonance Imaging: Iron Oxide-4A Nanocomposite
Background: Magnetic resonance imaging (MRI) contrast agents have an important role to differentiate healthy and diseased tissues. Access and design new contrast agents for the optimal use of MRI are necessary. This study aims to evaluate iron oxide–4A nanocomposite ability to act as a magnetic resonance imaging contrast agent.Materials and Methods: Iron oxide–4A nanocomposite (F4A) was syn...
متن کاملDesign of Novel Protein-based MRI Contrast Agernets with High Relaxivity and Stability for Biomedical Imaging
Magnetic resonance imaging (MRI) is the leading imaging technique for disease diagnostics. MRI contrast agents facilitate MRI technique to obtain tissue-specific image with improved sensitivity and signal-to-noise ratio. However, the applications of current MRI contrast agents are hampered by their uncontrolled blood circulation time, low relaxivity, and low specificity. To address such need, I...
متن کاملEuropium-engineered iron oxide nanocubes with high T1 and T2 contrast abilities for MRI in living subjects.
Magnetic resonance imaging (MRI) contrast agents with both positive (T1) and negative (T2) contrast abilities are needed in clinical diagnosis for fault-free accurate detection of lesions. We report a facile synthesis of europium-engineered iron oxide (EuIO) nanocubes as T1 and T2 contrast agents for MRI in living subjects. The Eu(iii) oxide-embedded iron oxide nanoparticles significantly incre...
متن کاملEffect of coating thickness of iron oxide nanoparticles on their relaxivity in the MRI
Objective(s):Iron oxide nanoparticles have found prevalent applications in various fields including drug delivery, cell separation and as contrast agents. Super paramagnetic iron oxide (SPIO) nanoparticles allow researchers and clinicians to enhance the tissue contrast of an area of interest by increasing the relaxation rate of water. In this study, we evaluate the dependency of hydrodynamic si...
متن کامل