S 1 Metal - substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity
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Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity.
Engineered metalloproteins constitute a flexible new class of analyte-sensitive molecular imaging agents detectable by magnetic resonance imaging (MRI), but their contrast effects are generally weaker than synthetic agents. To augment the proton relaxivity of agents derived from the heme domain of cytochrome P450 BM3 (BM3h), we formed manganese(III)-containing proteins that have higher electron...
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تاریخ انتشار 2010